SK channels and calmodulin
نویسندگان
چکیده
منابع مشابه
Control of Ca2+ Influx and Calmodulin Activation by SK-Channels in Dendritic Spines
The key trigger for Hebbian synaptic plasticity is influx of Ca2+ into postsynaptic dendritic spines. The magnitude of [Ca2+] increase caused by NMDA-receptor (NMDAR) and voltage-gated Ca2+ -channel (VGCC) activation is thought to determine both the amplitude and direction of synaptic plasticity by differential activation of Ca2+ -sensitive enzymes such as calmodulin. Ca2+ influx is negatively ...
متن کاملControl of Ca Influx and Calmodulin Activation by SK-Channels in Dendritic Spines
The key trigger for Hebbian synaptic plasticity is influx of Ca into postsynaptic dendritic spines. The magnitude of [Ca] increase caused by NMDA-receptor (NMDAR) and voltagegated Ca -channel (VGCC) activation is thought to determine both the amplitude and direction of synaptic plasticity by differential activation of Ca -sensitive enzymes such as calmodulin. Ca influx is negatively regulated b...
متن کاملEF hands at the N-lobe of calmodulin are required for both SK channel gating and stable SK–calmodulin interaction
Small conductance calcium-activated potassium (SK) channels respond to intracellular Ca(2+) via constitutively associated calmodulin (CaM). Previous studies have proposed a modular design for the interaction between CaM and SK channels. The C-lobe and the linker of CaM are thought to regulate the constitutive binding, whereas the N-lobe binds Ca(2+) and gates SK channels. However, we found that...
متن کاملFunctions of SK channels in central neurons.
1. SK channels are small-conductance calcium-activated potassium channels that are widely expressed in neurons. The traditional view of the functional role of SK channels is in mediating one component of the after-hyperpolarization that follows action potentials. Calcium influx via voltage-gated calcium channels active during action potentials opens SK channels and the resultant hyperpolarizati...
متن کاملCellular localisation and function of neuronal SK potassium channels
In the central nervous system, small conductance calcium-activated potassium channels (SK) are important for the generation of the afterhyperpolarisation that follows single or trains of action potentials. Three SK channels have been cloned (SKI, SK2 and SK3), which are selectively blocked by the venom toxin apamin and present distinct pharmacological properties. The principal aim of this work ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Channels
سال: 2015
ISSN: 1933-6950,1933-6969
DOI: 10.1080/19336950.2015.1029688